SYRE — Spyre Therapeutics Inc. price, chart and key statistics

Price data

Price

$79.90

YTD price return

+143.89%

YTD total return

+143.89%

Next earnings

Nov 3, 2026

Market cap

7B2016-12 1.5B2026-10 7B+382.6% over the window

Enterprise value

5.9B

Shares outstanding

88.2M2016-06 13.4M2026-06 88.2M+557.4% over the window

52W low

$21.15

52W high

$110.18

From 52W high

-27.48%

From 52W low

+277.87%

52W range

66%

Volume

Rel volume

0.88×

30D volume

1.4M

30D $ vol

124.4M

Fundamentals

EPS (ttm)

-$2.032020-12 -$1.522024-09 -$4.22+177.8% over the window

FCF (ttm)

-169.3M2015-12 -11.2M2024-12 -157.4M+1306.7% over the window

FCF/share

-$1.922015-12 -$14.782024-12 -$2.61-82.3% over the window

Book value/share

$12.492016-06 $5.512026-06 $12.49+126.6% over the window

ROE

-16.25%2016-06 -23.5%2026-06 -16.2%-30.9% over the window

ROA

-15.25%2016-06 -22.5%2026-06 -15.3%-32.1% over the window

Current ratio

18.532016-06 22.882026-06 18.53-19.0% over the window

Growth (CAGR, ttm) · 10Y

Shares

+46.02%2025-06-30 → 2026-06-3060.4M → 88.2M (+46.0% total)-4.49%2023-06-30 → 2026-06-30101.2M → 88.2M (-12.9% total)+12.44%2021-06-30 → 2026-06-3049.1M → 88.2M (+79.7% total)+20.72%2016-06-30 → 2026-06-3013.4M → 88.2M (+557.4% total)

Per-share growth (CAGR, ttm) · 10Y

Book value/share

+65.56%2025-06-30 → 2026-06-30$7.55 → $12.49 (+65.5% total)n/a+38.79%2021-06-30 → 2026-06-30$2.43 → $12.49 (+414.8% total)+8.52%2016-06-30 → 2026-06-30$5.51 → $12.49 (+126.6% total)

Price

+259.58%2025-10-16 → 2026-10-16$22.24 → $79.90 (+259.3% total)Price appreciation from split-adjusted daily closes, excluding dividends; endpoints are exact trading-day anniversaries of the latest close.+79.72%2023-10-16 → 2026-10-16$13.76 → $79.90 (+480.7% total)Price appreciation from split-adjusted daily closes, excluding dividends; endpoints are exact trading-day anniversaries of the latest close.-17.13%2021-10-15 → 2026-10-16$204.50 → $79.90 (-60.9% total)Price appreciation from split-adjusted daily closes, excluding dividends; endpoints are exact trading-day anniversaries of the latest close.-7.20%2016-10-14 → 2026-10-16$168.75 → $79.90 (-52.7% total)Price appreciation from split-adjusted daily closes, excluding dividends; endpoints are exact trading-day anniversaries of the latest close.

Total return

+259.58%2025-10-16 → 2026-10-16$22.24 → $79.90 (+259.3% total)Total return with dividends reinvested (adjusted daily closes); endpoints are exact trading-day anniversaries of the latest close. The gap against the Price row is the dividend contribution.+79.72%2023-10-16 → 2026-10-16$13.76 → $79.90 (+480.7% total)Total return with dividends reinvested (adjusted daily closes); endpoints are exact trading-day anniversaries of the latest close. The gap against the Price row is the dividend contribution.-17.13%2021-10-15 → 2026-10-16$204.50 → $79.90 (-60.9% total)Total return with dividends reinvested (adjusted daily closes); endpoints are exact trading-day anniversaries of the latest close. The gap against the Price row is the dividend contribution.-7.20%2016-10-14 → 2026-10-16$168.75 → $79.90 (-52.7% total)Total return with dividends reinvested (adjusted daily closes); endpoints are exact trading-day anniversaries of the latest close. The gap against the Price row is the dividend contribution.

Fundamentals end at the last reported quarter; price and total return end at the latest close.

Valuation

P/E (ttm)Price ÷ TTM diluted EPS. Net income carries everything below the operating line, including one-off gains. Negative when the trailing year lost money.

-39.4×2016-12 -72.302026-10 -39.40-45.5% over the window

Fwd P/E

-24.3×

P/B (mrq)Market cap ÷ stockholders' equity at the most recent quarter end.

6.4×2016-12 21.422026-10 6.40-70.1% over the window

FCF yield (ttm)TTM free cash flow ÷ market cap — the inverse of P/FCF.

-2.40%2016-09 -1.1%2024-12 -11.2%+960.6% over the window

Buyback yield (realized, 1y)1 − shares_at(2026-06-30) ÷ shares_at(2025-06-30) = 1 − 88.2M ÷ 60.4M. Point-in-time share counts from the company's own SEC filings (the same count at both ends), published only when the cash flow statement shows repurchases inside that window. A falling price can't inflate it; negative means net dilution.

-46.02%

Shareholder yield (realized, 1y)Buyback leg + dividend leg: shares retired over the year (-46.02%) + dividends paid over that year ($0) ÷ market_cap_at(2025-06-30) ($904.2M). Both legs are measured against the start of the window, so a payout can't shrink its own denominator.

-46.02%

Buyback yield (cash, ttm)Buybacks net of issuance over the trailing twelve months ($0) ÷ today's market cap ($7B). Dollars SPENT over what the company is worth NOW — a stock that fell after buying reads high.

0.00%2016-09 0.0%2026-06 0.0%

Shareholder yield (cash, ttm)(TTM buybacks net of issuance $0 + TTM dividends $0) ÷ today's market cap ($7B). Same caveat as the cash buyback yield.

0.00%2016-09 0.0%2026-06 0.0%

Vs own 10Y history

P/S

84th

P/B

21st