ALNY — Alnylam Pharmaceuticals Inc. price, chart and key statistics

Price data

Price

$165.04

YTD price return

-58.50%

YTD total return

-58.50%

Market cap

22.1B2016-12 3.2B2026-11 22.1B+588.1% over the window

Enterprise value

21.6B

Shares outstanding

133.9M2016-09 85.8M2026-09 133.9M+56.1% over the window

52W low

$149.18

52W high

$479.79

From 52W high

-65.60%

From 52W low

+10.63%

52W range

5%$149–$480

Beta

0.29

Volume

Rel volume

1.38×

30D volume

2.6M

30D $ vol

475.7M

Insider trading

Insider net 1W2 insider-days of buying ($543K) and 0 of selling (no priced lot) in the last 7 days, by transaction date, open-market transactions only — awards, exercises, tax withholding and employee-plan purchases are not counted. A Form 4 is filed within two business days of the trade, so the newest days may not be in yet.

+$543K

Insider net 1M2 insider-days of buying ($543K) and 0 of selling (no priced lot) in the last 30 days, by transaction date, open-market transactions only — awards, exercises, tax withholding and employee-plan purchases are not counted. A Form 4 is filed within two business days of the trade, so the newest days may not be in yet.

+$543K

Insider net 3M2 insider-days of buying ($543K) and 1 of selling ($399K) in the last 91 days, by transaction date, open-market transactions only — awards, exercises, tax withholding and employee-plan purchases are not counted. A Form 4 is filed within two business days of the trade, so the newest days may not be in yet.

+$144K

Insider net 1Y2 insider-days of buying ($543K) and 31 of selling ($26.9M) in the last 365 days, by transaction date, open-market transactions only — awards, exercises, tax withholding and employee-plan purchases are not counted. A Form 4 is filed within two business days of the trade, so the newest days may not be in yet.

−$26.3M

Form 4 transactions by trade date, as filed; latest on file 2026-11-10.

Fundamentals

Sales (ttm)

5B2016-12 47.2M2026-09 5B+10530.5% over the window

Sales/share

$37.432016-12 $0.552026-09 $37.43+6726.8% over the window

EPS (ttm)

$19.242019-12 -$8.112026-09 $19.24-337.2% over the window

FCF (ttm)

752.1M2016-09 -330.2M2026-09 752.1M-327.8% over the window

FCF/share

$5.622016-09 -$3.852026-09 $5.62-245.9% over the window

Book value/share

$26.912016-09 $11.832026-09 $26.91+127.5% over the window

Net margin

52.85%2016-12 -869.6%2026-09 52.8%-106.1% over the window

ROE

73.51%2016-09 -38.2%2026-09 73.5%-292.4% over the window

ROA

33.14%2016-09 -29.5%2026-09 33.1%-212.2% over the window

Debt / equity

0.18×2016-09 0.152026-09 0.18+22.2% over the window

Current ratio

2.482016-09 9.142026-09 2.48-72.9% over the window

Growth (CAGR, ttm) · 10Y

Sales

+56.22%2025-09-30 → 2026-09-303.2B → 5B (+56.2% total)+42.73%2023-09-30 → 2026-09-301.7B → 5B (+190.9% total)+46.26%2021-09-30 → 2026-09-30749.3M → 5B (+569.0% total)+61.41%2016-12-31 → 2026-09-3047.2M → 5B (+10530.5% total)

FCF

+350.33%2025-09-30 → 2026-09-30167.2M → 752.1M (+349.9% total)n/an/an/a

Shares

+1.38%2025-09-30 → 2026-09-30132.1M → 133.9M (+1.4% total)+2.19%2023-09-30 → 2026-09-30125.5M → 133.9M (+6.7% total)+2.29%2021-09-30 → 2026-09-30119.6M → 133.9M (+12.0% total)+4.55%2016-09-30 → 2026-09-3085.8M → 133.9M (+56.1% total)

Per-share growth (CAGR, ttm) · 10Y

EPS

+2043.63%2025-09-30 → 2026-09-30$0.90 → $19.24 (+2039.1% total)n/an/an/a

Sales/share

+54.09%2025-09-30 → 2026-09-30$24.30 → $37.43 (+54.0% total)+39.67%2023-09-30 → 2026-09-30$13.73 → $37.43 (+172.5% total)+42.98%2021-09-30 → 2026-09-30$6.27 → $37.43 (+497.4% total)+54.24%2016-12-31 → 2026-09-30$0.55 → $37.43 (+6726.8% total)

FCF/share

+344.20%2025-09-30 → 2026-09-30$1.27 → $5.62 (+343.7% total)n/an/an/a

Book value/share

+1422.66%2025-09-30 → 2026-09-30$1.77 → $26.91 (+1419.8% total)n/a+33.61%2021-09-30 → 2026-09-30$6.32 → $26.91 (+325.7% total)+8.57%2016-09-30 → 2026-09-30$11.83 → $26.91 (+127.5% total)

Price

-63.67%2025-11-13 → 2026-11-13$453.97 → $165.04 (-63.6% total)Price appreciation from split-adjusted daily closes, excluding dividends; endpoints are exact trading-day anniversaries of the latest close.+0.01%2023-11-13 → 2026-11-13$165.01 → $165.04 (+0.0% total)Price appreciation from split-adjusted daily closes, excluding dividends; endpoints are exact trading-day anniversaries of the latest close.-0.69%2021-11-12 → 2026-11-13$170.87 → $165.04 (-3.4% total)Price appreciation from split-adjusted daily closes, excluding dividends; endpoints are exact trading-day anniversaries of the latest close.+13.49%2016-11-11 → 2026-11-13$46.54 → $165.04 (+254.6% total)Price appreciation from split-adjusted daily closes, excluding dividends; endpoints are exact trading-day anniversaries of the latest close.

Total return

-63.67%2025-11-13 → 2026-11-13$453.97 → $165.04 (-63.6% total)Total return with dividends reinvested (adjusted daily closes); endpoints are exact trading-day anniversaries of the latest close. The gap against the Price row is the dividend contribution.+0.01%2023-11-13 → 2026-11-13$165.01 → $165.04 (+0.0% total)Total return with dividends reinvested (adjusted daily closes); endpoints are exact trading-day anniversaries of the latest close. The gap against the Price row is the dividend contribution.-0.69%2021-11-12 → 2026-11-13$170.87 → $165.04 (-3.4% total)Total return with dividends reinvested (adjusted daily closes); endpoints are exact trading-day anniversaries of the latest close. The gap against the Price row is the dividend contribution.+13.49%2016-11-11 → 2026-11-13$46.54 → $165.04 (+254.6% total)Total return with dividends reinvested (adjusted daily closes); endpoints are exact trading-day anniversaries of the latest close. The gap against the Price row is the dividend contribution.

Fundamentals end at the last reported quarter; price and total return end at the latest close.

Valuation

P/E (ttm)Price ÷ TTM diluted EPS. Net income carries everything below the operating line, including one-off gains. Negative when the trailing year lost money.

8.6×2016-12 -8.282026-11 8.34-200.7% over the window

Fwd P/E

14.7×

P/S (ttm)Market cap ÷ TTM revenue.

4.4×2018-03 132.292026-11 4.41-96.7% over the window

P/B (mrq)Market cap ÷ stockholders' equity at the most recent quarter end.

6.1×2016-12 3.172026-11 6.13+93.8% over the window

P/FCF (ttm)Market cap ÷ TTM free cash flow (operating cash flow − capex).

29.4×2016-12 -9.732026-11 29.39-402.1% over the window

EV/EBITDA (fy)

20.9×

EV/Sales (ttm)

4.3×

FCF yield (ttm)TTM free cash flow ÷ market cap — the inverse of P/FCF.

3.40%2016-09 -10.3%2026-09 2.3%-122.2% over the window

Buyback yield (realized, 1y)1 − shares_at(2026-09-30) ÷ shares_at(2025-09-30) = 1 − 133.9M ÷ 132.1M. Point-in-time share counts from the company's own SEC filings (the same count at both ends), published only when the cash flow statement shows repurchases inside that window. A falling price can't inflate it; negative means net dilution.

-1.38%

Shareholder yield (realized, 1y)Buyback leg + dividend leg: shares retired over the year (-1.38%) + dividends paid over that year ($0) ÷ market_cap_at(2025-09-30) ($60.1B). Both legs are measured against the start of the window, so a payout can't shrink its own denominator.

-1.38%

Shareholder yield (cash, ttm)(TTM buybacks net of issuance $0 + TTM dividends $0) ÷ today's market cap ($22.1B). Same caveat as the cash buyback yield.

0.00%2016-09 0.0%2025-09 0.0%

Vs own 10Y history

P/S

0th

P/B

22nd