How much would $1,000 invested in SYRE be worth today?

$1,000 invested in SYRE on October 17, 2016 would be worth $474 on October 16, 2026, with dividends reinvested — −7.2% a year compounded (CAGR).

How far back does the SYRE calculator go?

SYRE data begins April 7, 2016, with a close every session. Pick any start and end date in that span — 10 years, 6 months of history.

Does this include dividends?

Yes. The default "dividends reinvested" view uses split- and dividend-adjusted closing prices — a standard total-return approximation that excludes taxes and fees. A price-only view (split-adjusted, no dividends) is also available.

If You Invested $1,000 in Spyre Therapeutics (SYRE): What It Would Be Worth Today

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SYRE

$79.90-0.25%

as of close, Oct 16, 2026

☾ AH $79.90 -0.25%

Spyre Therapeutics Inc.Stock · HealthcareRussell 2000 0.2%Nasdaq Composite 0.02%US Stock Market 0.010%Russell 3000 0.009%

PeersMRNALLYMDTUNHJNJTMO

Your investment#

How much

All at once, on the start date

Pick start & end dates10 years

Start

Key dates

Start at a well-known dateRecentMarket topsMarket bottomsEvents

Bought at that day's close

End

Key dates

End at a well-known dateMarket topsMarket bottomsEvents

Latest close, Oct 16, 2026

Or drag the slider to set start and end dates

2016 to today, log scale

Covid2022 bear market

2018202020222024Oct 2016Today

Options

Result#

$1,000Oct 17, 2016$474Oct 16, 20260.47×your money

$1,000 invested in SYRE on October 17, 2016 was worth $474 on October 16, 2026, with dividends reinvested.

That’s −7.2% a year compounded (CAGR) over 10 years: 0.47 times your money.

Over the same dates the same $1,000 would be worth $4,208 in the S&P 500 and $6,511 in the Nasdaq-100: SYRE trailed both the S&P 500 and the Nasdaq-100.

Price only$474if dividends were spent

Biggest fall−99.0%Jun 22, 2020 to Jun 21, 2023

At a flat 5% a year$1,629a savings account's rate

Loss$526on $1,000 put in

How this period ranks#

Better than 29% of all 7 periods of 10 years since 2016.

Your dates

−100%0%690%

Worst: −10.2% a year, Apr 2016 to Apr 2026Best: −2.0% a year, Jul 2016 to Jul 2026

One scale for every length, so longer periods bunch up. Point at a bar.

Growth of $1,000 in SYRE, October 17, 2016 to October 16, 2026#

Your $1,000$Your buySame plan in the S&P 500The highA lowLog scale: equal steps are equal percentage moves

Lowest value$16 · Jun 2023Highest value$1,637 · Jun 2020$521 · Mar 2020$432 · Aug 2017$592 · Jan 2017$

$30$100$1,000$3,000$474

20182020202220242026

How far SYRE was below its previous high. The biggest fall: −99.0% from Jun 22, 2020 to Jun 21, 2023, not back to the high by the end date.

−99.0% from its high−68.1% from its high−63.8% from its high−40.8% from its high

high−99%

Your one buy. $1,000 on October 17, 2016, worth $474 on October 16, 2026. Pick Monthly or Yearly to see a plan's buys.

paid0.47×

What $1,000 would be worth on October 16, 2026, by start date#

Each point is the same amount invested that day and held to October 16, 2026, dividends reinvested. Above the line it made money.

Your start

$300$1,000$3,000$10k$30k

20182020202220242026

$1,000 invested in SYRE, by year#

Started on each year's first close and held to Oct 16, 2026, dividends reinvested.

Started	Worth Oct 16, 2026	Multiple	A year (CAGR)	Same in the Nasdaq-100
2017	$699	0.70×	−3.6%	$6,344
2018	$594	0.59×	−5.8%	$4,742
2019	$398	0.40×	−11.2%	$4,812
2020	$412	0.41×	−12.2%	$3,420
2021	$373	0.37×	−15.7%	$2,373
2022	$670	0.67×	−8.0%	$1,818
2023	$7,591	7.6×	70.9%	$2,741
2024	$3,734	3.7×	60.4%	$1,789
2025	$3,350	3.4×	96.9%	$1,403
2026	$2,613	2.6×	—	$1,162

Methodology#

A buy is made at the start date's close, or the next session's when the market was closed that day, and valued at the end date's close; a monthly or yearly plan buys on the same day of each month or year. "Dividends reinvested" uses split- and dividend-adjusted closes (a standard total-return approximation; taxes and fees excluded). "Price-only" uses split-adjusted closes. SYRE data begins April 7, 2016; values as of October 16, 2026 and refresh daily. The ranking compares month-end to month-end periods. Past performance does not predict future returns; not investment advice.

See the live SYRE chart and fundamentals on the SYRE quote page or the S&P 500 return calculator.

FAQ#

How much would $1,000 invested in SYRE be worth today?: $1,000 invested in SYRE on October 17, 2016 would be worth $474 on October 16, 2026, with dividends reinvested — −7.2% a year compounded (CAGR).
How far back does the SYRE calculator go?: SYRE data begins April 7, 2016, with a close every session. Pick any start and end date in that span — 10 years, 6 months of history.
Does this include dividends?: Yes. The default "dividends reinvested" view uses split- and dividend-adjusted closing prices — a standard total-return approximation that excludes taxes and fees. A price-only view (split-adjusted, no dividends) is also available.

SYRE return calculator