SYRE
$79.90-0.25%
Spyre Therapeutics Inc.Stock · HealthcareRussell 2000 0.2%Nasdaq Composite 0.02%US Stock Market 0.010%Russell 3000 0.009%
Spyre Therapeutics Inc. monthly returns
Spyre Therapeutics Inc. has averaged 3.57% per month, positive in 47% of months. Month-by-month returns for Spyre Therapeutics Inc. (SYRE) below, through October 16, 2026 — the table lists the most recent months; the bar chart plots the last 5 years.
Average month
+3.6%
118 months
Best month
+246.9%
Jun 2023
Worst month
-68.0%
Jun 2022
Positive months
47%
of all months
Spyre Therapeutics Inc. monthly returns#
| Month | Path | Total return |
|---|---|---|
| Oct 2026 | -10.3% | |
| Sep 2026 | -0.3% | |
| Aug 2026 | -9.2% | |
| Jul 2026 | +10.8% | |
| Jun 2026 | +20.8% | |
| May 2026 | -1.3% | |
| Apr 2026 | +47.6% | |
| Mar 2026 | +17.3% | |
| Feb 2026 | +34.5% | |
| Jan 2026 | -2.4% | |
| Dec 2025 | +9.2% | |
| Nov 2025 | +22.6% | |
| Oct 2025 | +45.9% | |
| Sep 2025 | +1.6% | |
| Aug 2025 | -2.8% | |
| Jul 2025 | +13.4% | |
| Jun 2025 | -2.0% | |
| May 2025 | +0.3% | |
| Apr 2025 | -5.6% | |
| Mar 2025 | -18.1% | |
| Feb 2025 | -14.3% | |
| Jan 2025 | -1.2% | |
| Dec 2024 | -18.1% | |
| Nov 2024 | -12.6% | |
| Oct 2024 | +10.6% | |
| Sep 2024 | +2.3% | |
| Aug 2024 | +4.5% | |
| Jul 2024 | +17.0% | |
| Jun 2024 | -32.7% | |
| May 2024 | +5.8% | |
| Apr 2024 | -12.9% | |
| Mar 2024 | +38.2% | |
| Feb 2024 | +5.9% | |
| Jan 2024 | +20.4% | |
| Dec 2023 | +15.3% | |
| Nov 2023 | +60.3% | |
| Oct 2023 | -5.0% | |
| Sep 2023 | -14.8% | |
| Aug 2023 | +1.8% | |
| Jul 2023 | +25.3% | |
| Jun 2023 | +246.9% | |
| May 2023 | -23.1% | |
| Apr 2023 | -41.7% | |
| Mar 2023 | -26.0% | |
| Feb 2023 | -21.6% | |
| Jan 2023 | +11.1% | |
| Dec 2022 | +8.4% | |
| Nov 2022 | -59.7% | |
| Oct 2022 | +95.8% | |
| Sep 2022 | +0.6% | |
| Aug 2022 | +26.0% | |
| Jul 2022 | -17.8% | |
| Jun 2022 | -68.0% | |
| May 2022 | +9.7% | |
| Apr 2022 | -37.4% | |
| Mar 2022 | -17.0% | |
| Feb 2022 | -35.6% | |
| Jan 2022 | -9.5% | |
| Dec 2021 | -23.9% | |
| Nov 2021 | -14.8% | |
| Oct 2021 | -7.9% | |
| Sep 2021 | +9.7% | |
| Aug 2021 | +18.3% | |
| Jul 2021 | -11.9% | |
| Jun 2021 | +5.3% | |
| May 2021 | -15.0% | |
| Apr 2021 | -1.8% | |
| Mar 2021 | +6.3% | |
| Feb 2021 | +7.2% | |
| Jan 2021 | -11.7% | |
| Dec 2020 | -8.1% | |
| Nov 2020 | +11.5% | |
| Oct 2020 | +8.3% | |
| Sep 2020 | -2.5% | |
| Aug 2020 | +6.2% | |
| Jul 2020 | -25.9% | |
| Jun 2020 | +5.0% | |
| May 2020 | +13.4% | |
| Apr 2020 | +66.7% | |
| Mar 2020 | -31.8% | |
| Feb 2020 | -5.9% | |
| Jan 2020 | -5.0% | |
| Dec 2019 | -10.6% | |
| Nov 2019 | +12.4% | |
| Oct 2019 | -1.0% | |
| Sep 2019 | -1.5% | |
| Aug 2019 | -12.9% | |
| Jul 2019 | +30.8% | |
| Jun 2019 | +9.8% | |
| May 2019 | -8.9% | |
| Apr 2019 | -14.9% | |
| Mar 2019 | -3.7% | |
| Feb 2019 | -8.5% | |
| Jan 2019 | +22.0% | |
| Dec 2018 | -11.0% | |
| Nov 2018 | -2.4% | |
| Oct 2018 | -9.8% | |
| Sep 2018 | -12.4% | |
| Aug 2018 | +30.0% | |
| Jul 2018 | -20.5% | |
| Jun 2018 | -0.9% | |
| May 2018 | +14.3% | |
| Apr 2018 | -5.8% | |
| Mar 2018 | +36.8% | |
| Feb 2018 | +11.9% | |
| Jan 2018 | +19.8% | |
| Dec 2017 | +35.3% | |
| Nov 2017 | -8.7% | |
| Oct 2017 | -11.2% | |
| Sep 2017 | +20.0% | |
| Aug 2017 | +20.5% | |
| Jul 2017 | -11.4% | |
| Jun 2017 | -8.8% | |
| May 2017 | -41.0% | |
| Apr 2017 | -4.0% | |
| Mar 2017 | +20.2% | |
| Feb 2017 | +55.4% | |
| Jan 2017 | -8.3% | |
| Dec 2016 | -15.9% | |
| Nov 2016 | -3.5% |
Monthly total return (since Nov 2021)#
-200%-100%0%100%200%
Nov 2021-15%
Dec 2021-24%
Jan 2022-9.5%2022
Feb 2022-36%
Mar 2022-17%
Apr 2022-37%
May 2022+9.7%
Jun 2022-68%
Jul 2022-18%
Aug 2022+26%
Sep 2022+0.57%
Oct 2022+96%
Nov 2022-60%
Dec 2022+8.4%
Jan 2023+11%2023
Feb 2023-22%
Mar 2023-26%
Apr 2023-42%
May 2023-23%
Jun 2023+247%
Jul 2023+25%
Aug 2023+1.8%
Sep 2023-15%
Oct 2023-5.0%
Nov 2023+60%
Dec 2023+15%
Jan 2024+20%2024
Feb 2024+5.9%
Mar 2024+38%
Apr 2024-13%
May 2024+5.8%
Jun 2024-33%
Jul 2024+17%
Aug 2024+4.5%
Sep 2024+2.3%
Oct 2024+11%
Nov 2024-13%
Dec 2024-18%
Jan 2025-1.2%2025
Feb 2025-14%
Mar 2025-18%
Apr 2025-5.6%
May 2025+0.33%
Jun 2025-2.0%
Jul 2025+13%
Aug 2025-2.8%
Sep 2025+1.6%
Oct 2025+46%
Nov 2025+23%
Dec 2025+9.2%
Jan 2026-2.4%2026
Feb 2026+34%
Mar 2026+17%
Apr 2026+48%
May 2026-1.3%
Jun 2026+21%
Jul 2026+11%
Aug 2026-9.2%
Sep 2026-0.34%
Oct 2026-10%
Spyre Therapeutics Inc. returns by calendar month#
Every month of every year since 2017, one tick per year on a shared scale; the dark bar is the month's average. Total returns, dividends reinvested.
October 2026 so far: -10.26% — 9th of 10 Octobers since 2017 at the last close; the average October returned +14.0%.
| Month | −250%0+250% | Average | Median | Up | Best | Worst |
|---|---|---|---|---|---|---|
| Jan | +3.5% | -1.8% | 40% | +22.0% 2019 | -11.7% 2021 | |
| Feb | +2.9% | -0.0% | 50% | +55.4% 2017 | -35.6% 2022 | |
| Mar | +2.2% | +1.3% | 50% | +38.2% 2024 | -31.8% 2020 | |
| Apr | -1.0% | -5.7% | 20% | +66.7% 2020 | -41.7% 2023 | |
| May | -4.6% | -0.5% | 50% | +14.3% 2018 | -41.0% 2017 | |
| Jun | +17.5% | +2.0% | 50% | +246.9% 2023 | -68.0% 2022 | |
| Jul | +1.0% | -0.3% | 50% | +30.8% 2019 | -25.9% 2020 | |
| Aug | +8.2% | +5.4% | 70% | +30.0% 2018 | -12.9% 2019 | |
| Sep | +0.3% | +0.1% | 50% | +20.0% 2017 | -14.8% 2023 | |
| Oct | +14.0% | -1.0% | 44% | +95.8% 2022 | -11.2% 2017 | |
| Nov | +1.0% | -2.4% | 44% | +60.3% 2023 | -59.7% 2022 | |
| Dec | -0.4% | -8.1% | 44% | +35.3% 2017 | -23.9% 2021 |
Methodology#
Monthly returns are total returns (dividends reinvested), computed from SYRE's split- and dividend-adjusted month-end closes. The table shows the most recent 120 months and the bar chart the most recent 60. See the year-by-year returns for the annual view. Past performance does not predict future returns; not investment advice.
FAQ#
- What is Spyre Therapeutics Inc.'s average monthly return?
- Spyre Therapeutics Inc. (SYRE) has averaged about 3.57% per month, positive in roughly 47% of months. The best month was Jun 2023 (+246.9%) and the worst was Jun 2022 (-68.0%).
More on Spyre Therapeutics Inc.
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