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SYRE
$79.90-0.25%
as of close, Oct 16, 2026
☾ AH $79.90 -0.25%
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Spyre Therapeutics Inc. drawdown: 73.3% below the all-time high (price)

Spyre Therapeutics Inc. is 73.3% below its all-time high, set Apr 8, 2016 (as of market close, Oct 16, 2026), measured on price alone — dividends are not included, the convention headlines and crash histories use. The chart shows every day as a percentage of the highest level reached up to that point: 100% means a fresh record, everything below is a drawdown.

Below all-time high
−73.3%
26.7% of ATH
All-time high
$299.75
Apr 8, 2016
Time below the high
10.5 yrs
since Apr 8, 2016
Worst-ever drawdown
−99.1%
Jun 21, 2023
Longest underwater
10.5 yrs
between all-time highs
Today's level first reached
Apr 7, 2016
10.5 yrs ago
Last time this deep
never before
no prior −73.3% episode

% of all-time high since 2016: price#

The classic underwater chart (drawdown curve), drawn as % of the all-time high — 100% is a fresh record, everything below it is time spent underwater. Basis and range are in the URL, so a particular view is a link.

Basis
Range
All-time high = 100%20%40%60%80%
SYRE close · log5.0020.00100
20182020202220242026

The deepest drawdowns on record#

Every decline of 15% or more from an all-time high (price basis), deepest first.

PeakTroughDepthPeak → troughRecovered byUnderwater
Apr 8, 2016Jun 21, 2023−99.1%7.2 yrsnot yet10.5 yrs+

Price basis (no dividends) — the convention crash histories use. With dividends reinvested, recoveries arrive years earlier; switch the basis on the chart above to see it.

Drawdown vs what came next#

One dot per month since 2016: how far Spyre Therapeutics Inc. stood below its all-time high, and the total return over the following 1, 5 and 10 years.

1950–19992000–today

Read this with survivorship bias in mind: a single asset's history is one surviving sample, so past recoveries here say little about the odds ahead. Monthly windows also overlap heavily (they are not independent samples). Not investment advice.

FAQ#

How far is Spyre Therapeutics Inc. from its all-time high?
Spyre Therapeutics Inc. is currently 73.3% below its all-time high, set Apr 8, 2016 (as of market close, Oct 16, 2026). Prices only, the convention headlines use; with dividends reinvested the gap is usually smaller.
What was the biggest Spyre Therapeutics Inc. drawdown ever?
The deepest decline on record in our data (since 2016) took Spyre Therapeutics Inc. 99.1% below its prior high, bottoming Jun 21, 2023. The table on this page lists every major episode with its peak, trough and recovery date.

Methodology & related#

Daily data since -1 from SYRE; no free deep history exists for Spyre Therapeutics Inc. — for a 150-year drawdown record see the S&P 500 drawdown page. The price basis excludes dividends; the total-return basis reinvests them; the real basis additionally deflates by CPI. See also returns by year. Past performance does not predict future returns; not investment advice.

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