SEPN
$39.35+8.16%
Septerna Inc.Stock · HealthcareRussell 2000 · 0.02% of IWMNasdaq Composite · 0.005% of ONEQUS Stock Market · 0.001% of VTIRussell 3000 · 0.001% of IWV
Septerna Inc. weekly returns
Septerna Inc. has averaged 1.31% per week, positive in 54% of weeks. Week-by-week returns for Septerna Inc. (SEPN) below, through October 20, 2026 — the table lists the most recent weeks; the bar chart plots the last 2 years.
Average week
+1.3%
104 weeks
Best week
+47.1%
May 16, 2025
Worst week
-55.2%
Feb 21, 2025
Positive weeks
54%
of all weeks
Septerna Inc. weekly returns#
| Week ending | Path | Total return |
|---|---|---|
| Oct 20, 2026 | +8.3% | |
| Oct 16, 2026 | -5.3% | |
| Oct 9, 2026 | +1.8% | |
| Oct 2, 2026 | -0.2% | |
| Sep 25, 2026 | -2.4% | |
| Sep 18, 2026 | +0.5% | |
| Sep 11, 2026 | +4.8% | |
| Sep 4, 2026 | -5.6% | |
| Aug 28, 2026 | -2.7% | |
| Aug 21, 2026 | -10.1% | |
| Aug 14, 2026 | +14.6% | |
| Aug 7, 2026 | +12.7% | |
| Jul 31, 2026 | +4.1% | |
| Jul 24, 2026 | -0.9% | |
| Jul 17, 2026 | -7.0% | |
| Jul 10, 2026 | +5.7% | |
| Jul 2, 2026 | -8.9% | |
| Jun 26, 2026 | +3.2% | |
| Jun 18, 2026 | +0.6% | |
| Jun 12, 2026 | +15.4% | |
| Jun 5, 2026 | +3.1% | |
| May 29, 2026 | +6.5% | |
| May 22, 2026 | +5.2% | |
| May 15, 2026 | +12.9% | |
| May 8, 2026 | +1.1% | |
| May 1, 2026 | -4.3% | |
| Apr 24, 2026 | -5.6% | |
| Apr 17, 2026 | +13.2% | |
| Apr 10, 2026 | -8.3% | |
| Apr 2, 2026 | +5.5% | |
| Mar 27, 2026 | -1.3% | |
| Mar 20, 2026 | -3.8% | |
| Mar 13, 2026 | -12.6% | |
| Mar 6, 2026 | -0.8% | |
| Feb 27, 2026 | +6.4% | |
| Feb 20, 2026 | -0.8% | |
| Feb 13, 2026 | +8.2% | |
| Feb 6, 2026 | +8.9% | |
| Jan 30, 2026 | -9.4% | |
| Jan 23, 2026 | -1.2% | |
| Jan 16, 2026 | +3.0% | |
| Jan 9, 2026 | -9.6% | |
| Jan 2, 2026 | -2.2% | |
| Dec 26, 2025 | -3.2% | |
| Dec 19, 2025 | +16.3% | |
| Dec 12, 2025 | -4.9% | |
| Dec 5, 2025 | -7.8% | |
| Nov 28, 2025 | +13.5% | |
| Nov 21, 2025 | +9.9% | |
| Nov 14, 2025 | +25.7% | |
| Nov 7, 2025 | -10.1% | |
| Oct 31, 2025 | -4.9% | |
| Oct 24, 2025 | -1.8% | |
| Oct 17, 2025 | -4.4% | |
| Oct 10, 2025 | +11.6% | |
| Oct 3, 2025 | +18.5% | |
| Sep 26, 2025 | +11.1% | |
| Sep 19, 2025 | +9.9% | |
| Sep 12, 2025 | -1.0% | |
| Sep 5, 2025 | +19.3% | |
| Aug 29, 2025 | +0.9% | |
| Aug 22, 2025 | +2.3% | |
| Aug 15, 2025 | +0.3% | |
| Aug 8, 2025 | -4.3% | |
| Aug 1, 2025 | -12.0% | |
| Jul 25, 2025 | +10.6% | |
| Jul 18, 2025 | +7.0% | |
| Jul 11, 2025 | +3.2% | |
| Jul 3, 2025 | +8.2% | |
| Jun 27, 2025 | +0.4% | |
| Jun 20, 2025 | +2.9% | |
| Jun 13, 2025 | -0.4% | |
| Jun 6, 2025 | +10.4% | |
| May 30, 2025 | +0.7% | |
| May 23, 2025 | -6.6% | |
| May 16, 2025 | +47.1% | |
| May 9, 2025 | -10.6% | |
| May 2, 2025 | +15.8% | |
| Apr 25, 2025 | +9.5% | |
| Apr 17, 2025 | +3.1% | |
| Apr 11, 2025 | +4.4% | |
| Apr 4, 2025 | -10.2% | |
| Mar 28, 2025 | +3.0% | |
| Mar 21, 2025 | -6.0% | |
| Mar 14, 2025 | -2.0% | |
| Mar 7, 2025 | -0.6% | |
| Feb 28, 2025 | +11.6% | |
| Feb 21, 2025 | -55.2% | |
| Feb 14, 2025 | -1.0% | |
| Feb 7, 2025 | -22.6% | |
| Jan 31, 2025 | -8.5% | |
| Jan 24, 2025 | +9.4% | |
| Jan 17, 2025 | -6.1% | |
| Jan 10, 2025 | -24.1% | |
| Jan 3, 2025 | -6.5% | |
| Dec 27, 2024 | +4.3% | |
| Dec 20, 2024 | +8.4% | |
| Dec 13, 2024 | -13.0% | |
| Dec 6, 2024 | +1.8% | |
| Nov 29, 2024 | +15.0% | |
| Nov 22, 2024 | -2.4% | |
| Nov 15, 2024 | -13.0% | |
| Nov 8, 2024 | +18.9% | |
| Nov 1, 2024 | +1.8% |
Weekly total return (since Nov 1, 2024)#
-40%-20%0%20%40%
Nov 1, 2024+1.8%
Nov 8, 2024+19%
Nov 15, 2024-13%
Nov 22, 2024-2.4%
Nov 29, 2024+15%
Dec 6, 2024+1.8%
Dec 13, 2024-13%
Dec 20, 2024+8.4%
Dec 27, 2024+4.3%
Jan 3, 2025-6.5%2025
Jan 10, 2025-24%
Jan 17, 2025-6.1%
Jan 24, 2025+9.4%
Jan 31, 2025-8.5%
Feb 7, 2025-23%
Feb 14, 2025-0.99%
Feb 21, 2025-55%
Feb 28, 2025+12%
Mar 7, 2025-0.62%
Mar 14, 2025-2.0%
Mar 21, 2025-6.0%
Mar 28, 2025+3.0%
Apr 4, 2025-10%
Apr 11, 2025+4.4%
Apr 17, 2025+3.1%
Apr 25, 2025+9.5%
May 2, 2025+16%
May 9, 2025-11%
May 16, 2025+47%
May 23, 2025-6.6%
May 30, 2025+0.65%
Jun 6, 2025+10%
Jun 13, 2025-0.39%
Jun 20, 2025+2.9%
Jun 27, 2025+0.38%
Jul 3, 2025+8.2%
Jul 11, 2025+3.2%
Jul 18, 2025+7.0%
Jul 25, 2025+11%
Aug 1, 2025-12%
Aug 8, 2025-4.3%
Aug 15, 2025+0.26%
Aug 22, 2025+2.3%
Aug 29, 2025+0.92%
Sep 5, 2025+19%
Sep 12, 2025-1.0%
Sep 19, 2025+9.9%
Sep 26, 2025+11%
Oct 3, 2025+19%
Oct 10, 2025+12%
Oct 17, 2025-4.4%
Oct 24, 2025-1.8%
Oct 31, 2025-4.9%
Nov 7, 2025-10%
Nov 14, 2025+26%
Nov 21, 2025+9.9%
Nov 28, 2025+14%
Dec 5, 2025-7.8%
Dec 12, 2025-4.9%
Dec 19, 2025+16%
Dec 26, 2025-3.2%
Jan 2, 2026-2.2%2026
Jan 9, 2026-9.6%
Jan 16, 2026+3.0%
Jan 23, 2026-1.2%
Jan 30, 2026-9.4%
Feb 6, 2026+8.9%
Feb 13, 2026+8.2%
Feb 20, 2026-0.8%
Feb 27, 2026+6.4%
Mar 6, 2026-0.83%
Mar 13, 2026-13%
Mar 20, 2026-3.8%
Mar 27, 2026-1.3%
Apr 2, 2026+5.5%
Apr 10, 2026-8.3%
Apr 17, 2026+13%
Apr 24, 2026-5.6%
May 1, 2026-4.3%
May 8, 2026+1.1%
May 15, 2026+13%
May 22, 2026+5.2%
May 29, 2026+6.5%
Jun 5, 2026+3.1%
Jun 12, 2026+15%
Jun 18, 2026+0.61%
Jun 26, 2026+3.2%
Jul 2, 2026-8.9%
Jul 10, 2026+5.7%
Jul 17, 2026-7.0%
Jul 24, 2026-0.9%
Jul 31, 2026+4.1%
Aug 7, 2026+13%
Aug 14, 2026+15%
Aug 21, 2026-10%
Aug 28, 2026-2.7%
Sep 4, 2026-5.6%
Sep 11, 2026+4.8%
Sep 18, 2026+0.47%
Sep 25, 2026-2.4%
Oct 2, 2026-0.16%
Oct 9, 2026+1.8%
Oct 16, 2026-5.3%
Oct 20, 2026+8.3%
Methodology#
Weekly returns are total returns (dividends reinvested), computed from SEPN's split- and dividend-adjusted weekly (ISO week) closes. The table shows the most recent 260 weeks and the bar chart the most recent 104. See the year-by-year returns for the annual view. Past performance does not predict future returns; not investment advice.
FAQ#
- What is Septerna Inc.'s average weekly return?
- Septerna Inc. (SEPN) has averaged about 1.31% per week, positive in roughly 54% of weeks. The best week was May 16, 2025 (+47.1%) and the worst was Feb 21, 2025 (-55.2%).
More on Septerna Inc.
By week for: S&P 500 · S&P 500 Equal Weight · US Stock Market · Nasdaq-100