SEPN — Septerna Inc. price, chart and key statistics

Price data

Price

$39.35

YTD price return

+41.14%

YTD total return

+41.14%

Next earnings

Nov 9, 2026

Market cap

1.8B2024-12 1B2026-10 1.8B+80.5% over the window

Enterprise value

1.5B

Shares outstanding

46.7M2023-12 3.2M2026-06 46.7M+1373.3% over the window

52W low

$17.55

52W high

$51.10

From 52W high

-22.99%

From 52W low

+124.22%

52W range

65%

Volume

Rel volume

1.05×

30D volume

398.4K

30D $ vol

15.1M

Fundamentals

Sales (ttm)

98.9M2023-12 151K2026-06 98.9M+65384.8% over the window

Sales/share

$2.122023-12 $0.052026-06 $2.12+4344.7% over the window

EPS (ttm)

-$0.542023-12 $0.292026-06 -$0.54-285.7% over the window

FCF (ttm)

105.1M2023-12 -41.6M2026-06 105.1M-352.6% over the window

FCF/share

$2.252023-12 -$13.132026-06 $2.25-117.1% over the window

Book value/share

$8.292023-12 -$12.112026-06 $8.29-168.4% over the window

Net margin

-24.51%2023-12 2768.2%2026-06 -24.5%-100.9% over the window

ROE

-6.27%2024-12 -17.1%2026-06 -6.3%-63.3% over the window

ROA

-4.28%2023-12 3.2%2026-06 -4.3%-233.9% over the window

Current ratio

4.992023-12 16.302026-06 4.99-69.4% over the window

Growth (CAGR, ttm) · 10Y

Sales

+13566.03%2025-06-30 → 2026-06-30726K → 98.9M (+13520.1% total)+1242.29%2023-12-31 → 2026-06-30151K → 98.9M (+65384.8% total)n/an/a

Shares

+4.70%2025-06-30 → 2026-06-3044.6M → 46.7M (+4.7% total)+193.69%2023-12-31 → 2026-06-303.2M → 46.7M (+1373.3% total)n/an/a

Per-share growth (CAGR, ttm) · 10Y

Sales/share

+12953.18%2025-06-30 → 2026-06-30$0.02 → $2.12 (+12909.7% total)+357.04%2023-12-31 → 2026-06-30$0.05 → $2.12 (+4344.7% total)n/an/a

Book value/share

-2.16%2025-06-30 → 2026-06-30$8.47 → $8.29 (-2.2% total)n/an/an/a

Price

+75.42%2025-10-20 → 2026-10-20$22.44 → $39.35 (+75.4% total)Price appreciation from split-adjusted daily closes, excluding dividends; endpoints are exact trading-day anniversaries of the latest close.n/an/an/a

Total return

+75.42%2025-10-20 → 2026-10-20$22.44 → $39.35 (+75.4% total)Total return with dividends reinvested (adjusted daily closes); endpoints are exact trading-day anniversaries of the latest close. The gap against the Price row is the dividend contribution.n/an/an/a

Fundamentals end at the last reported quarter; price and total return end at the latest close.

Valuation

P/E (ttm)Price ÷ TTM diluted EPS. Net income carries everything below the operating line, including one-off gains. Negative when the trailing year lost money.

-73.1×2024-12 -14.172026-10 -75.79+434.6% over the window

Fwd P/E

-18.8×

P/S (ttm)Market cap ÷ TTM revenue.

18.6×2024-12 946.732026-10 18.58-98.0% over the window

P/B (mrq)Market cap ÷ stockholders' equity at the most recent quarter end.

4.7×2024-12 2.422026-10 4.75+96.0% over the window

P/FCF (ttm)Market cap ÷ TTM free cash flow (operating cash flow − capex).

17.5×2024-12 -14.632026-10 17.48-219.5% over the window

EV/Sales (ttm)

15.0×

FCF yield (ttm)TTM free cash flow ÷ market cap — the inverse of P/FCF.

5.72%2024-12 -6.8%2026-06 6.7%-198.3% over the window

Buyback yield (realized, 1y)1 − shares_at(2026-06-30) ÷ shares_at(2025-06-30) = 1 − 46.7M ÷ 44.6M. Point-in-time share counts from the company's own SEC filings (the same count at both ends), published only when the cash flow statement shows repurchases inside that window. A falling price can't inflate it; negative means net dilution.

-4.70%

Shareholder yield (realized, 1y)Buyback leg + dividend leg: shares retired over the year (-4.70%) + dividends paid over that year ($0) ÷ market_cap_at(2025-06-30) ($471.3M). Both legs are measured against the start of the window, so a payout can't shrink its own denominator.

-4.70%

Buyback yield (cash, ttm)Buybacks net of issuance over the trailing twelve months ($-13.8M) ÷ today's market cap ($1.8B). Dollars SPENT over what the company is worth NOW — a stock that fell after buying reads high.

-0.75%2024-12 0.0%2026-06 -0.9%

Shareholder yield (cash, ttm)(TTM buybacks net of issuance $-13.8M + TTM dividends $0) ÷ today's market cap ($1.8B). Same caveat as the cash buyback yield.

-0.75%2024-12 0.0%2026-06 -0.9%