VRTX — Vertex Pharmaceuticals Incorporated price, chart and key statistics

Price data

Price

$521.03

YTD price return

+14.93%

YTD total return

+14.93%

Next earnings

Nov 2, 2026 · After close

Market cap

132.1B2016-12 18.3B2026-10 132.1B+622.8% over the window

Enterprise value

126.2B

Shares outstanding

253.5M2016-06 247.8M2026-06 253.5M+2.3% over the window

52W low

$403.16

52W high

$560.25

From 52W high

-7.00%

From 52W low

+29.24%

52W range

75%

Beta

0.30

Volume

Rel volume

0.85×

30D volume

1.2M

30D $ vol

614.1M

Insider trading

Insider net 1WNo open-market insider purchase or sale with a transaction date in the last 7 days, as filed on Form 4.

none

Insider net 1MNo open-market insider purchase or sale with a transaction date in the last 30 days, as filed on Form 4.

none

Insider net 3MNo open-market insider purchase or sale with a transaction date in the last 91 days, as filed on Form 4.

none

Insider net 1Y0 insider-days of buying (no priced lot) and 51 of selling ($87.5M) in the last 365 days, by transaction date, open-market transactions only — awards, exercises, tax withholding and employee-plan purchases are not counted. A Form 4 is filed within two business days of the trade, so the newest days may not be in yet.

−$87.5M

Form 4 transactions by trade date, as filed; latest on file 2026-07-02.

Fundamentals

Sales (ttm)

12.6B2016-06 1.6B2026-06 12.6B+708.2% over the window

Sales/share

$49.662016-06 $6.292026-06 $49.66+690.1% over the window

EPS (ttm)

$17.192016-06 -$1.132026-06 $17.19-1620.4% over the window

FCF (ttm)

3.8B2016-06 -56.4M2026-06 3.8B-6827.9% over the window

FCF/share

$14.982016-06 -$0.232026-06 $14.98-6677.1% over the window

Book value/share

$79.892016-06 $3.962026-06 $79.89+1917.0% over the window

Net margin

35.00%2016-06 -17.7%2026-06 35.0%-298.2% over the window

ROE

21.76%2016-06 -28.0%2026-06 21.8%-177.6% over the window

ROA

16.06%2016-06 -10.8%2026-06 16.1%-248.9% over the window

Current ratio

3.192016-06 2.332026-06 3.19+36.4% over the window

Growth (CAGR, ttm) · 10Y

Sales

+10.24%2025-06-30 → 2026-06-3011.4B → 12.6B (+10.2% total)+9.81%2023-06-30 → 2026-06-309.5B → 12.6B (+32.4% total)+13.50%2021-06-30 → 2026-06-306.7B → 12.6B (+88.3% total)+23.24%2016-06-30 → 2026-06-301.6B → 12.6B (+708.2% total)

Net income

+21.12%2025-06-30 → 2026-06-303.6B → 4.4B (+21.1% total)+9.39%2023-06-30 → 2026-06-303.4B → 4.4B (+30.9% total)+17.21%2021-06-30 → 2026-06-302B → 4.4B (+121.2% total)n/a

FCF

+8.48%2025-06-30 → 2026-06-303.5B → 3.8B (+8.5% total)-0.71%2023-06-30 → 2026-06-303.9B → 3.8B (-2.1% total)+16.39%2021-06-30 → 2026-06-301.8B → 3.8B (+113.6% total)n/a

Shares

-1.14%2025-06-30 → 2026-06-30256.4M → 253.5M (-1.1% total)-0.60%2023-06-30 → 2026-06-30258.1M → 253.5M (-1.8% total)-0.46%2021-06-30 → 2026-06-30259.4M → 253.5M (-2.3% total)+0.23%2016-06-30 → 2026-06-30247.8M → 253.5M (+2.3% total)

Per-share growth (CAGR, ttm) · 10Y

EPS

+22.47%2025-06-30 → 2026-06-30$14.04 → $17.19 (+22.4% total)+9.93%2023-06-30 → 2026-06-30$12.94 → $17.19 (+32.9% total)+17.79%2021-06-30 → 2026-06-30$7.58 → $17.19 (+126.7% total)n/a

Sales/share

+11.51%2025-06-30 → 2026-06-30$44.54 → $49.66 (+11.5% total)+10.48%2023-06-30 → 2026-06-30$36.83 → $49.66 (+34.8% total)+14.03%2021-06-30 → 2026-06-30$25.76 → $49.66 (+92.8% total)+22.96%2016-06-30 → 2026-06-30$6.29 → $49.66 (+690.1% total)

FCF/share

+9.73%2025-06-30 → 2026-06-30$13.65 → $14.98 (+9.7% total)-0.11%2023-06-30 → 2026-06-30$15.03 → $14.98 (-0.3% total)+16.94%2021-06-30 → 2026-06-30$6.85 → $14.98 (+118.6% total)n/a

Book value/share

+19.27%2025-06-30 → 2026-06-30$66.99 → $79.89 (+19.3% total)+10.05%2023-06-30 → 2026-06-30$59.94 → $79.89 (+33.3% total)+17.65%2021-06-30 → 2026-06-30$35.45 → $79.89 (+125.4% total)+35.05%2016-06-30 → 2026-06-30$3.96 → $79.89 (+1917.0% total)

Price

+24.02%2025-10-27 → 2026-10-27$420.17 → $521.03 (+24.0% total)Price appreciation from split-adjusted daily closes, excluding dividends; endpoints are exact trading-day anniversaries of the latest close.+13.61%2023-10-27 → 2026-10-27$355.28 → $521.03 (+46.7% total)Price appreciation from split-adjusted daily closes, excluding dividends; endpoints are exact trading-day anniversaries of the latest close.+23.56%2021-10-27 → 2026-10-27$180.94 → $521.03 (+188.0% total)Price appreciation from split-adjusted daily closes, excluding dividends; endpoints are exact trading-day anniversaries of the latest close.+20.80%2016-10-26 → 2026-10-27$78.71 → $521.03 (+562.0% total)Price appreciation from split-adjusted daily closes, excluding dividends; endpoints are exact trading-day anniversaries of the latest close.

Total return

+24.02%2025-10-27 → 2026-10-27$420.17 → $521.03 (+24.0% total)Total return with dividends reinvested (adjusted daily closes); endpoints are exact trading-day anniversaries of the latest close. The gap against the Price row is the dividend contribution.+13.61%2023-10-27 → 2026-10-27$355.28 → $521.03 (+46.7% total)Total return with dividends reinvested (adjusted daily closes); endpoints are exact trading-day anniversaries of the latest close. The gap against the Price row is the dividend contribution.+23.56%2021-10-27 → 2026-10-27$180.94 → $521.03 (+188.0% total)Total return with dividends reinvested (adjusted daily closes); endpoints are exact trading-day anniversaries of the latest close. The gap against the Price row is the dividend contribution.+20.80%2016-10-26 → 2026-10-27$78.71 → $521.03 (+562.0% total)Total return with dividends reinvested (adjusted daily closes); endpoints are exact trading-day anniversaries of the latest close. The gap against the Price row is the dividend contribution.

Fundamentals end at the last reported quarter; price and total return end at the latest close.

Valuation

P/E (ttm)Price ÷ TTM diluted EPS. Net income carries everything below the operating line, including one-off gains. Negative when the trailing year lost money.

30.3×2016-12 -83.542026-10 29.98-135.9% over the window

P/OI (ttm)Price ÷ TTM operating income. Excludes the below-the-line items that make P/E jump — mark-to-market gains, settlements, tax true-ups.

27.6×2016-12 -219.082026-10 27.65-112.6% over the window

Fwd P/E

25.7×

P/S (ttm)Market cap ÷ TTM revenue.

10.5×2016-12 11.002026-10 10.49-4.6% over the window

P/B (mrq)Market cap ÷ stockholders' equity at the most recent quarter end.

6.5×2016-12 17.892026-10 6.52-63.5% over the window

P/FCF (ttm)Market cap ÷ TTM free cash flow (operating cash flow − capex).

34.8×2016-12 275.942026-10 34.79-87.4% over the window

EV/EBITDA (fy)

25.3×

EV/Sales (ttm)

10.0×

FCF yield (ttm)TTM free cash flow ÷ market cap — the inverse of P/FCF.

2.87%2016-09 0.4%2026-06 3.0%+727.5% over the window

Buyback yield (realized, 1y)1 − shares_at(2026-06-30) ÷ shares_at(2025-06-30) = 1 − 253.5M ÷ 256.4M. Point-in-time share counts from the company's own SEC filings (the same count at both ends), published only when the cash flow statement shows repurchases inside that window. A falling price can't inflate it; negative means net dilution.

1.14%

Shareholder yield (realized, 1y)Buyback leg + dividend leg: shares retired over the year (1.14%) + dividends paid over that year ($0) ÷ market_cap_at(2025-06-30) ($114.1B). Both legs are measured against the start of the window, so a payout can't shrink its own denominator.

1.14%

Buyback yield (cash, ttm)Buybacks net of issuance over the trailing twelve months ($2B) ÷ today's market cap ($132.1B). Dollars SPENT over what the company is worth NOW — a stock that fell after buying reads high.

1.52%2016-09 0.0%2026-06 1.6%

Shareholder yield (cash, ttm)(TTM buybacks net of issuance $2B + TTM dividends $0) ÷ today's market cap ($132.1B). Same caveat as the cash buyback yield.

1.52%2016-09 0.0%2026-06 1.6%

Vs own 10Y history

P/E

63rd

P/OI

50th

P/S

47th

P/B

43rd

P/FCF

60th