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XBI
SPDR S&P Biotech ETFETF · Themes
$160.11+$0.58 (+0.36%)as of market close, Aug 18, 2026
☾ After hours:$160.37+0.16%4:29 PM ET
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XBI returns by year

SPDR S&P Biotech ETF has returned +11.6% annually (CAGR) since 2007. Calendar-year, monthly and weekly total returns for SPDR S&P Biotech ETF (XBI) below, through August 18, 2026 — the most recent year is year-to-date.

Annualized (CAGR)
+11.6%
2007–2026
Average year
+14.5%
19 full years
Best year
+48.4%
2013
Worst year
-25.9%
2022
Positive years
14/19
74% up

SPDR S&P Biotech ETF returns by year (20072026)#

Calendar-year returns with each year's path and its dividend contribution (dividend return = total minus price return).

SPDR S&P Biotech ETF annual returns by year
YearTotal return
2026YTD
+29.9%
2025
+35.9%
2024
+1.0%
2023
+7.6%
2022
-25.9%
2021
-20.4%
2020
+48.3%
2019
+32.6%
2018
-15.3%
2017
+43.8%
2016
-15.4%
2015
+13.6%
2014
+45.0%
2013
+48.4%
2012
+32.7%

Total return by period

-40%-20%+0%+20%+40%
'07'09'11'13'15'17'19'21'23'25

Methodology#

Returns are total returns (dividends reinvested), computed from XBI's split- and dividend-adjusted closes. The bar chart switches between annual and monthly periods. Annualized return is the compound annual growth rate over the full period. The current year is year-to-date. See also the periodic table of returns. Past performance does not predict future returns; not investment advice.

See also: S&P 500 · Nasdaq-100 · Dow Jones · Russell 2000 · US Bond Market · Gold · Silver · Bitcoin · Ethereum

FAQ#

What is SPDR S&P Biotech ETF's average annual return?
Since 2007, SPDR S&P Biotech ETF (XBI) has returned about 11.6% a year (the compound annual growth rate) and an average calendar-year return of 14.5%.
What were SPDR S&P Biotech ETF's best and worst years?
Over 2007–2026, the best year was 2013 (+48.4%) and the worst was 2022 (-25.9%).
How often is SPDR S&P Biotech ETF up in a year?
14 of the 19 full years since 2007 were positive — about 74% of the time.