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XBI
$144.32-3.65%
as of close, Oct 16, 2026
☾ AH $144.32 -3.65%
SPDR S&P Biotech ETFETF · Themes
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SPDR S&P Biotech ETF total returns by year (including dividends)

As of market close, Oct 16, 2026

SPDR S&P Biotech ETF total returns by year (2007–2026)#

SPDR S&P Biotech ETF annual returns by year
YearTotal return
2026YTD
+18.5%
2025
+35.9%
2024
+1.0%
2023
+7.6%
2022
-25.9%
2021
-20.4%
2020
+48.3%
2019
+32.6%
2018
-15.3%
2017
+43.8%
2016
-15.4%
2015
+13.4%
2014
+43.8%
2013
+48.2%
2012
+32.5%
2011
+5.3%
2010
+17.6%
2009
+0.1%
2008
-9.3%
2007
+28.8%
Annualized
+10.9%
2007–2026
Average year
+14.3%
19 full years
Best year
+48.3%
2020
Worst year
-25.9%
2022
Positive years
14/19
74% up

Total return by period#

Annual

Methodology#

Total returns, dividends reinvested, measured on XBI. Annualized return is the compound annual growth rate; the current year is year-to-date. Past performance does not predict future returns.

FAQ#

What is SPDR S&P Biotech ETF's average annual return?
Since 2007, SPDR S&P Biotech ETF (XBI) has returned about 10.9% a year (the compound annual growth rate) and an average calendar-year return of 14.3%.
What were SPDR S&P Biotech ETF's best and worst years?
Over 2007–2026, the best year was 2020 (+48.3%) and the worst was 2022 (-25.9%).
How often is SPDR S&P Biotech ETF up in a year?
14 of the 19 full years since 2007 were positive — about 74% of the time.

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