What is SPDR S&P Biotech ETF's average annual return?

Since 2007, SPDR S&P Biotech ETF (XBI) has returned about 11.7% a year (the compound annual growth rate) and an average calendar-year return of 14.5%.

What were SPDR S&P Biotech ETF's best and worst years?

Over 2007–2026, the best year was 2013 (+48.4%) and the worst was 2022 (-25.9%).

How often is SPDR S&P Biotech ETF up in a year?

14 of the 19 full years since 2007 were positive — about 74% of the time.

XBI

SPDR S&P Biotech ETFETF · Themes

$160.46+$3.91 (+2.50%)as of market close, Jul 2, 2026

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XBI returns by year

SPDR S&P Biotech ETF has returned +11.7% annually (CAGR) since 2007. Calendar-year, monthly and weekly total returns for SPDR S&P Biotech ETF (XBI) below, through July 2, 2026 — the most recent year is year-to-date.

Annualized (CAGR)

+11.7%

2007–2026

Average year

+14.5%

19 full years

Best year

+48.4%

2013

Worst year

-25.9%

2022

Positive years

14/19

74% up

SPDR S&P Biotech ETF returns by year (2007–2026)#

Calendar-year returns with each year's path and its dividend contribution (dividend return = total minus price return).

SPDR S&P Biotech ETF annual returns by year
Year	Start price	End price	Dividend	Total return
2026YTD	$121.93	$160.46	+0.0%	+31.6%
2025	$90.06	$121.93	+0.5%	+35.9%
2024	$89.29	$90.06	+0.1%	+1.0%
2023	$83.00	$89.29	+0.0%	+7.6%
2022	$111.96	$83.00	+0.0%	-25.9%
2021	$140.78	$111.96	+0.0%	-20.4%
2020	$95.11	$140.78	+0.3%	+48.3%
2019	$71.75	$95.11	+0.0%	+32.6%
2018	$84.87	$71.75	+0.2%	-15.3%
2017	$59.19	$84.87	+0.4%	+43.8%
2016	$70.20	$59.19	+0.2%	-15.4%
2015	$62.15	$70.20	+0.6%	+13.6%
2014	$43.40	$62.15	+1.8%	+45.0%
2013	$29.30	$43.40	+0.3%	+48.4%
2012	$22.13	$29.30	+0.3%	+32.7%
2011	$21.03	$22.13	+0.0%	+5.3%
2010	$17.88	$21.03	+0.0%	+17.6%
2009	$17.87	$17.88	+0.3%	+0.4%
2008	$19.79	$17.87	+1.0%	-8.6%
2007	$15.38	$19.79	+0.4%	+29.0%

Total return by period

-40%-20%+0%+20%+40%

'07'09'11'13'15'17'19'21'23'25

Methodology#

Returns are total returns (dividends reinvested), computed from XBI's split- and dividend-adjusted closes. The bar chart switches between annual and monthly periods. Annualized return is the compound annual growth rate over the full period. The current year is year-to-date. See also the periodic table of returns. Past performance does not predict future returns; not investment advice.

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FAQ

What is SPDR S&P Biotech ETF's average annual return?: Since 2007, SPDR S&P Biotech ETF (XBI) has returned about 11.7% a year (the compound annual growth rate) and an average calendar-year return of 14.5%.
What were SPDR S&P Biotech ETF's best and worst years?: Over 2007–2026, the best year was 2013 (+48.4%) and the worst was 2022 (-25.9%).
How often is SPDR S&P Biotech ETF up in a year?: 14 of the 19 full years since 2007 were positive — about 74% of the time.