XBI
SPDR S&P Biotech ETFETF · Themes$156.20-0.40%
as of market close, Sep 11, 2026
☾ AH — —
SPDR S&P Biotech ETF monthly returns
SPDR S&P Biotech ETF has averaged 1.31% per month, positive in 57% of months. Month-by-month returns for SPDR S&P Biotech ETF (XBI) below, through September 11, 2026 — the table lists the most recent months; the bar chart plots the last 5 years.
Average month
+1.3%
237 months
Best month
+20.6%
Apr 2020
Worst month
-28.0%
Jan 2016
Positive months
57%
of all months
SPDR S&P Biotech ETF monthly returns#
| Month | Path | Total return |
|---|---|---|
| Sep 2026 | -3.9% | |
| Aug 2026 | +10.5% | |
| Jul 2026 | -7.9% | |
| Jun 2026 | +16.9% | |
| May 2026 | +4.1% | |
| Apr 2026 | +2.8% | |
| Mar 2026 | +0.3% | |
| Feb 2026 | +2.1% | |
| Jan 2026 | +2.3% | |
| Dec 2025 | -0.7% | |
| Nov 2025 | +9.3% | |
| Oct 2025 | +12.5% | |
| Sep 2025 | +11.6% | |
| Aug 2025 | +4.9% | |
| Jul 2025 | +3.3% | |
| Jun 2025 | +4.7% | |
| May 2025 | -4.5% | |
| Apr 2025 | +2.3% | |
| Mar 2025 | -8.6% | |
| Feb 2025 | -4.3% | |
| Jan 2025 | +2.9% | |
| Dec 2024 | -9.6% | |
| Nov 2024 | +2.7% | |
| Oct 2024 | -1.8% | |
| Sep 2024 | -2.4% | |
| Aug 2024 | +2.2% | |
| Jul 2024 | +6.8% | |
| Jun 2024 | +4.1% | |
| May 2024 | +5.3% | |
| Apr 2024 | -10.8% | |
| Mar 2024 | -3.6% | |
| Feb 2024 | +12.6% | |
| Jan 2024 | -2.1% | |
| Dec 2023 | +18.3% | |
| Nov 2023 | +14.0% | |
| Oct 2023 | -9.3% | |
| Sep 2023 | -7.8% | |
| Aug 2023 | -6.0% | |
| Jul 2023 | +1.3% | |
| Jun 2023 | -0.9% | |
| May 2023 | +4.6% | |
| Apr 2023 | +5.2% | |
| Mar 2023 | -8.0% | |
| Feb 2023 | -6.8% | |
| Jan 2023 | +7.1% | |
| Dec 2022 | -0.7% | |
| Nov 2022 | +1.8% | |
| Oct 2022 | +3.6% | |
| Sep 2022 | -5.2% | |
| Aug 2022 | +3.2% | |
| Jul 2022 | +9.2% | |
| Jun 2022 | +8.0% | |
| May 2022 | -6.8% | |
| Apr 2022 | -17.9% | |
| Mar 2022 | +0.1% | |
| Feb 2022 | -3.9% | |
| Jan 2022 | -16.6% | |
| Dec 2021 | -3.7% | |
| Nov 2021 | -6.8% | |
| Oct 2021 | -0.7% | |
| Sep 2021 | -5.4% | |
| Aug 2021 | +7.6% | |
| Jul 2021 | -8.9% | |
| Jun 2021 | +5.7% | |
| May 2021 | -6.2% | |
| Apr 2021 | +0.7% | |
| Mar 2021 | -8.3% | |
| Feb 2021 | -3.2% | |
| Jan 2021 | +8.6% | |
| Dec 2020 | +5.8% | |
| Nov 2020 | +18.1% | |
| Oct 2020 | +1.2% | |
| Sep 2020 | -0.3% | |
| Aug 2020 | +2.3% | |
| Jul 2020 | -2.3% | |
| Jun 2020 | +8.1% | |
| May 2020 | +10.9% | |
| Apr 2020 | +20.6% | |
| Mar 2020 | -13.2% | |
| Feb 2020 | +0.1% | |
| Jan 2020 | -6.3% | |
| Dec 2019 | +1.6% | |
| Nov 2019 | +14.7% | |
| Oct 2019 | +7.1% | |
| Sep 2019 | -5.1% | |
| Aug 2019 | -6.2% | |
| Jul 2019 | -2.3% | |
| Jun 2019 | +10.4% | |
| May 2019 | -6.8% | |
| Apr 2019 | -5.9% | |
| Mar 2019 | +1.6% | |
| Feb 2019 | +6.6% | |
| Jan 2019 | +16.5% | |
| Dec 2018 | -12.1% | |
| Nov 2018 | +3.2% | |
| Oct 2018 | -17.5% | |
| Sep 2018 | -4.2% | |
| Aug 2018 | +5.1% | |
| Jul 2018 | +0.1% | |
| Jun 2018 | +0.6% | |
| May 2018 | +8.8% | |
| Apr 2018 | -0.9% | |
| Mar 2018 | -2.8% | |
| Feb 2018 | -3.2% | |
| Jan 2018 | +10.0% | |
| Dec 2017 | +2.1% | |
| Nov 2017 | -0.5% | |
| Oct 2017 | -3.4% | |
| Sep 2017 | +3.3% | |
| Aug 2017 | +7.2% | |
| Jul 2017 | +1.3% | |
| Jun 2017 | +14.2% | |
| May 2017 | -5.2% | |
| Apr 2017 | +3.0% | |
| Mar 2017 | -1.2% | |
| Feb 2017 | +8.2% | |
| Jan 2017 | +9.6% | |
| Dec 2016 | -5.5% | |
| Nov 2016 | +11.6% | |
| Oct 2016 | -15.3% |
Monthly total return (since Oct 2021)#
-10%0%10%
Oct 2021-0.72%
Nov 2021-6.8%
Dec 2021-3.7%
Jan 2022-17%2022
Feb 2022-3.9%
Mar 2022+0.06%
Apr 2022-18%
May 2022-6.8%
Jun 2022+8.0%
Jul 2022+9.2%
Aug 2022+3.2%
Sep 2022-5.2%
Oct 2022+3.6%
Nov 2022+1.8%
Dec 2022-0.74%
Jan 2023+7.1%2023
Feb 2023-6.8%
Mar 2023-8.0%
Apr 2023+5.2%
May 2023+4.6%
Jun 2023-0.85%
Jul 2023+1.3%
Aug 2023-6.0%
Sep 2023-7.8%
Oct 2023-9.3%
Nov 2023+14%
Dec 2023+18%
Jan 2024-2.1%2024
Feb 2024+13%
Mar 2024-3.6%
Apr 2024-11%
May 2024+5.3%
Jun 2024+4.1%
Jul 2024+6.8%
Aug 2024+2.2%
Sep 2024-2.4%
Oct 2024-1.8%
Nov 2024+2.7%
Dec 2024-9.6%
Jan 2025+2.9%2025
Feb 2025-4.3%
Mar 2025-8.6%
Apr 2025+2.3%
May 2025-4.5%
Jun 2025+4.7%
Jul 2025+3.3%
Aug 2025+4.9%
Sep 2025+12%
Oct 2025+12%
Nov 2025+9.3%
Dec 2025-0.67%
Jan 2026+2.3%2026
Feb 2026+2.1%
Mar 2026+0.28%
Apr 2026+2.8%
May 2026+4.1%
Jun 2026+17%
Jul 2026-7.9%
Aug 2026+11%
Sep 2026-3.9%
Methodology#
Monthly returns are total returns (dividends reinvested), computed from XBI's split- and dividend-adjusted month-end closes. The table shows the most recent 120 months and the bar chart the most recent 60. See the year-by-year returns for the annual view. Past performance does not predict future returns; not investment advice.
FAQ#
- What is SPDR S&P Biotech ETF's average monthly return?
- SPDR S&P Biotech ETF (XBI) has averaged about 1.31% per month, positive in roughly 57% of months. The best month was Apr 2020 (+20.6%) and the worst was Jan 2016 (-28.0%).
More on SPDR S&P Biotech ETF
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