What is SPDR S&P Biotech ETF's average monthly return?

SPDR S&P Biotech ETF has averaged about 1.33% per month, positive in roughly 58% of months.

XBI

SPDR S&P Biotech ETFETF · Themes

$160.46+$3.91 (+2.50%)as of market close, Jul 2, 2026

XBI monthly returns

SPDR S&P Biotech ETF has averaged 1.33% per month, positive in 58% of months. Month-by-month returns for SPDR S&P Biotech ETF (XBI) below, through July 2, 2026 — the table lists the most recent months; the bar chart plots the last 5 years.

Average month

+1.3%

235 months

Best month

+20.6%

Apr 2020

Worst month

-28.0%

Jan 2016

Positive months

58%

of all months

SPDR S&P Biotech ETF monthly returns#

SPDR S&P Biotech ETF total return by month
Month	Path	Total return
Jul 2026		+1.4%
Jun 2026		+15.8%
May 2026		+4.1%
Apr 2026		+2.8%
Mar 2026		+0.3%
Feb 2026		+2.1%
Jan 2026		+2.3%
Dec 2025		-0.7%
Nov 2025		+9.3%
Oct 2025		+12.5%
Sep 2025		+11.6%
Aug 2025		+4.9%
Jul 2025		+3.3%
Jun 2025		+4.7%
May 2025		-4.5%
Apr 2025		+2.3%
Mar 2025		-8.6%
Feb 2025		-4.3%
Jan 2025		+2.9%
Dec 2024		-9.6%
Nov 2024		+2.7%
Oct 2024		-1.8%
Sep 2024		-2.4%
Aug 2024		+2.2%
Jul 2024		+6.8%
Jun 2024		+4.1%
May 2024		+5.3%
Apr 2024		-10.8%
Mar 2024		-3.6%
Feb 2024		+12.6%
Jan 2024		-2.1%
Dec 2023		+18.3%
Nov 2023		+14.0%
Oct 2023		-9.3%
Sep 2023		-7.8%
Aug 2023		-6.0%
Jul 2023		+1.3%
Jun 2023		-0.9%
May 2023		+4.6%
Apr 2023		+5.2%
Mar 2023		-8.0%
Feb 2023		-6.8%
Jan 2023		+7.1%
Dec 2022		-0.7%
Nov 2022		+1.8%
Oct 2022		+3.6%
Sep 2022		-5.2%
Aug 2022		+3.2%
Jul 2022		+9.2%
Jun 2022		+8.0%
May 2022		-6.8%
Apr 2022		-17.9%
Mar 2022		+0.1%
Feb 2022		-3.9%
Jan 2022		-16.6%
Dec 2021		-3.7%
Nov 2021		-6.8%
Oct 2021		-0.7%
Sep 2021		-5.4%
Aug 2021		+7.6%
Jul 2021		-8.9%
Jun 2021		+5.7%
May 2021		-6.2%
Apr 2021		+0.7%
Mar 2021		-8.3%
Feb 2021		-3.2%
Jan 2021		+8.6%
Dec 2020		+5.8%
Nov 2020		+18.1%
Oct 2020		+1.2%
Sep 2020		-0.3%
Aug 2020		+2.3%
Jul 2020		-2.3%
Jun 2020		+8.1%
May 2020		+10.9%
Apr 2020		+20.6%
Mar 2020		-13.2%
Feb 2020		+0.1%
Jan 2020		-6.3%
Dec 2019		+1.6%
Nov 2019		+14.7%
Oct 2019		+7.1%
Sep 2019		-5.1%
Aug 2019		-6.2%
Jul 2019		-2.3%
Jun 2019		+10.4%
May 2019		-6.8%
Apr 2019		-5.9%
Mar 2019		+1.6%
Feb 2019		+6.6%
Jan 2019		+16.5%
Dec 2018		-12.1%
Nov 2018		+3.2%
Oct 2018		-17.5%
Sep 2018		-4.2%
Aug 2018		+5.1%
Jul 2018		+0.1%
Jun 2018		+0.6%
May 2018		+8.8%
Apr 2018		-0.9%
Mar 2018		-2.8%
Feb 2018		-3.2%
Jan 2018		+10.0%
Dec 2017		+2.1%
Nov 2017		-0.5%
Oct 2017		-3.4%
Sep 2017		+3.3%
Aug 2017		+7.2%
Jul 2017		+1.3%
Jun 2017		+14.2%
May 2017		-5.2%
Apr 2017		+3.0%
Mar 2017		-1.2%
Feb 2017		+8.2%
Jan 2017		+9.6%
Dec 2016		-5.5%
Nov 2016		+11.6%
Oct 2016		-15.3%
Sep 2016		+10.4%
Aug 2016		-3.2%

Monthly total return (since Aug 2021)

-10%+0%+10%

20222023202420252026

Methodology#

Monthly returns are total returns (dividends reinvested), computed from XBI's split- and dividend-adjusted month-end closes. The table shows the most recent 120 months and the bar chart the most recent 60. See the year-by-year returns for the annual view. Past performance does not predict future returns; not investment advice.

See also: S&P 500 · Nasdaq-100 · Dow Jones · Russell 2000 · US Bond Market · Gold · Silver · Bitcoin · Ethereum

FAQ

What is SPDR S&P Biotech ETF's average monthly return?: SPDR S&P Biotech ETF (XBI) has averaged about 1.33% per month, positive in roughly 58% of months. The best month was Apr 2020 (+20.6%) and the worst was Jan 2016 (-28.0%).