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PRAX
Praxis Precision Medicines Inc.Stock · Health Care · Russell 2000 0.3%
$368.47−$17.86 (-4.62%)as of market close, Aug 13, 2026
☾ After hours:$368.46+0.00%3:59 PM ET
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PRAX returns by year

Praxis Precision Medicines Inc. has returned -5.9% annually (CAGR) since 2021. Calendar-year, monthly and weekly total returns for Praxis Precision Medicines Inc. (PRAX) below, through August 13, 2026 — the most recent year is year-to-date.

Annualized (CAGR)
-5.9%
2021–2026
Average year
+67.7%
5 full years
Best year
+283.0%
2025
Worst year
-87.9%
2022
Positive years
2/5
40% up

Praxis Precision Medicines Inc. returns by year (20212026)#

Calendar-year returns with each year's path and its dividend contribution (dividend return = total minus price return).

Praxis Precision Medicines Inc. annual returns by year
YearTotal return
2026YTD
+25.1%
2025
+283.0%
2024
+245.4%
2023
-37.6%
2022
-87.9%
2021
-64.2%

Total return by period

-200%-100%+0%+100%+200%
'21'22'23'24'25'26

Methodology#

Returns are total returns (dividends reinvested), computed from PRAX's split- and dividend-adjusted closes. The bar chart switches between annual and monthly periods. Annualized return is the compound annual growth rate over the full period. The current year is year-to-date. See also the periodic table of returns. Past performance does not predict future returns; not investment advice.

See also: S&P 500 · Nasdaq-100 · Dow Jones · Russell 2000 · US Bond Market · Gold · Silver · Bitcoin · Ethereum

FAQ#

What is Praxis Precision Medicines Inc.'s average annual return?
Since 2021, Praxis Precision Medicines Inc. (PRAX) has returned about -5.9% a year (the compound annual growth rate) and an average calendar-year return of 67.7%.
What were Praxis Precision Medicines Inc.'s best and worst years?
Over 2021–2026, the best year was 2025 (+283.0%) and the worst was 2022 (-87.9%).
How often is Praxis Precision Medicines Inc. up in a year?
2 of the 5 full years since 2021 were positive — about 40% of the time.